Formulation and optimization of nano-sized ethosomes for enhanced transdermal delivery of cromolyn sodium
نویسندگان
چکیده
منابع مشابه
Ethosomes: a Novel Nano Vesicular Carrier for Enhanced Dermal, Transdermal and Intracellular Drug Delivery
Ethosomes are ethanolic liposomes, a novel lipid vesicular carrier prepared using phospholipid, ethanol and water. Instead of rupturing the liposomal structure while increasing the ethanol concentration, vesicles superior in delivering the active ingredient into the deeper layers of the skin was obtained, named as ethosomes. In contrast to the liposomes and deformable liposomes, ethosomes have ...
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The aim of this study was to improve the transdermal permeation of Diclofenac sodium, a poorly water-soluble drug, employing conventional liposomes, ethosomes, and transfersomes. The prepared formulations had been characterized for the loaded drug amount and vesicle size. The prepared vesicular systems were incorporated into 1% Carbopol 914 gel, and a survey of in vitro drug release and drug re...
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The current investigation aimed to evaluate the transdermal potential of novel testosterone propionate (TP) ethosomes and liposomes prepared by surfactant modification. The effect of hexadecyl trimethyl ammonium bromide and cremophor EL-35 on the particle size and zeta potential of the prepared vesicles was investigated. The entrapment efficiency and stability, as well as in vitro and in vivo s...
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materials and methods liposomes were prepared by thin film method using soya lecithin and cholesterol. physicochemical characteristics of the liposomes such as, particle size, drug encapsulation efficiency were determined. also, drug release and in vitro skin permeability through rat skin were evaluated using franz diffusion cells. results the results showed that the maximum drug encapsulation ...
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Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Bioallied Sciences
سال: 2012
ISSN: 0975-7406
DOI: 10.4103/0975-7406.103274